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Post-learning survey and evaluation

After completing this module, we would like to understand your knowledge and understanding about the science behind CF and CFTR modulator therapy, as well as evaluate your experience and satisfaction with this module. The survey has a total of 9 mandatory questions and 2 optional questions. Please allow around 5 minutes to complete it.

Part 6: CFTR modulator therapies in practice

  • Clinical reflections - instructions
  • Who’s on your team?
  • Confirming CFTR gene variants and genetic test results
  • Interpreting genetic test results
  • Explaining CFTR mutations to patients
  • Module summary
Duration: 10-12 minutes (approx.)

Part 5: Therapeutic approaches targeting CFTR gene variants

  • Treatment evolution
  • Types of CFTR modulator therapies
  • F508del: a minimal function mutation that can be corrected
  • CFTR modulator discovery
  • Translational science in action: CFTR modulator development
Duration: 10-15 minutes (approx.)

Part 4: Impact of CFTR genotype on phenotype

  • Phenotype versus genotype
  • CFTR gene variants and CF disease phenotype
  • Relationship between CFTR function and phenotype
Duration: 5-10 minutes (approx.)

Part 3: Understanding CFTR variants – types of mutations and their impact

  • Variety of CFTR gene variants identified
  • CFTR quantity and function
  • Classes of CFTR gene variants
  • Classifying gene variants by function
  • Minimal function mutations
  • Impaired gating mutations
  • Residual function mutations
  • F508del characteristics
  • Useful resources
Duration: 10-15 minutes (approx.)

Part 2: Principles of transcription, translation, and genetic mutations

  • Central principle of molecular biology
  • Gene variants impact protein form and function
  • Ways genes can be altered
  • Gene variant naming formats
Duration: 10-15 minutes (approx.)

Part 1: Cystic fibrosis – an overview

  • CFTR gene mutations cause CF
  • Role CFTR protein
  • CFTR mutations are inherited
Duration: 5-10 minutes (approx.)

Introduction

  • CFTR mutations in CF: introduction
  • Learning outcomes
  • Module overview
Duration: 2 - 3 minutes (approx.)

Pre-learning survey

Prior to commencing this module, we would like to discern your current knowledge and understanding of the science behind CF and CFTR modulator therapy through this survey. The survey has a total of 4 questions. Please allow around 2 minutes to complete it.

Post-learning survey and evaluation

Part 6: CFTR modulator therapies in practice

Part 5: Therapeutic approaches targeting CFTR gene variants

Part 4: Impact of CFTR genotype on phenotype

Part 3: Understanding CFTR variants – types of mutations and their impact

Part 2: Principles of transcription, translation, and genetic mutations

Part 1: Cystic fibrosis – an overview

Lesson 5 – summary and assessment

Post-learning survey and evaluation

After completing this module, we would like to understand your knowledge, understanding and attitudes towards mental health in CF, as well as evaluate your experience and satisfaction with this module. The survey has a total of 16 mandatory questions and 2 optional questions. Please allow around 5-10 minutes to complete it.

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